Intermediate- and high-risk prostate cancer: a plea for high-dose, high-precision intensity-modulated radiotherapy with a modulated duration of androgen deprivation therapy.

摘要

Zelefsky et al [1] report a retrospective analysis of 2251 patients with Tl-3 NO-X MO prostate cancer (PCa) divided into groups of 571 low-risk (22.4%), 1074 intermediate-risk (42.1%), and 906 high-risk (35.5%) patients, according to the National Comprehensive Cancer Network classification. Patients were scanned in the treatment position and anatomic data were transferred to the 3D treatment planning system, where prostate and seminal vesicles were delineated and then surrounded by a security margin. They were treated with three-dimensional (3D) conformal radiotherapy (CRT) or intensity-modulated radiotherapy (IMRT), performed on prostate and seminal vesicles only. During irradiation, a multileaf collimator adapts automatically and continually to the contours of the target volume seen by each beam.