Structure-to-activity studies of chemopreventive and tumor cell cytotoxic effects of chalcones and cyclic chalcone analogues

摘要

Objective: Chalcone is a generic term given to compounds bearing the l,3-diphenylprop-2-en-l-one framework. Chalcone-containing plants, such as the Angelica, Glycyrrhiza, Piper and Ruscus species, have long been used as medical treatments in Asia, Africa and South America. Chalcones are readily synthesized in the laboratory and the literature is reach in references to structural modifications of the chalcone template. Chalcone is a unique template that is associated with a diverse range of pharmacological activities, among which cytotoxicity, anti-tumor (chemopreventive), antiinflammatory, antiplasmodial and antioxidant properties are widely cited.