Ingestion of Salmon Nasal Cartilage-Derived Proteoglycan Improves Skin Condition: A Randomized, Double-Blind, Controlled Study

摘要

Background: Proteoglycan is one of the components of the extracellular matrix with various biological activities and has been used as the functional foods to improve knee joint health or skin condition.Objective: To examine the effect of ingestion of salmon (Oncorhynchus keta, Salmonidae) nasal cartilage-derived proteoglycan (sPG) on skin condition, we performed a randomized, double-blind, controlled study in healthy adult volunteers.Methods: Recruited subjects (n=156) were men and women, ages 21-62 years. From this population, we selected 19 subjects based on the exclusion criteria of the guidelines for evaluation of cosmetic functions of Japanese Cosmetic Science Society. Subjects were randomly divided into an sPG group (n=10; mean age, 39.1 years) and a placebo group (n=9; mean age, 39.6 years). The characteristics of the sPG used in this study were assessed by HPLC and electrophoresis analysis.