Is primary tumour resection associated with survival improvement in patients with colorectal cancer and unresectable synchronous metastases? A pooled analysis of individual data from four randomised trials

Faron Matthieu; Pignon Jean-Pierre; Malka David; Bourredjem Abderrahmane; Douillard Jean-Yves; Adenis Antoine; Elias Dominique; Bouche Olivier; Ducreux Michel

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Is primary tumour resection associated with survival improvement in patients with colorectal cancer and unresectable synchronous metastases? A pooled analysis of individual data from four randomised trials

机译：大肠癌和无法切除的同步转移患者的原发肿瘤切除是否与生存改善相关？汇总来自四个随机试验的单个数据的分析

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摘要

Objective: To evaluate the impact on survival of primary tumour resection in patients with unresectable synchronous metastases from colorectal cancer (CRC).

机译：目的：评估结直肠癌（CRC）无法切除的同步转移对原发肿瘤切除术生存的影响。

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《European journal of cancer: official journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)》 |2015年第2期|共11页
作者
Faron Matthieu; Pignon Jean-Pierre; Malka David; Bourredjem Abderrahmane; Douillard Jean-Yves; Adenis Antoine; Elias Dominique; Bouche Olivier; Ducreux Michel;
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正文语种 eng
中图分类肿瘤学;
关键词
Colorectal cancer; Metastasis; Chemotherapy; Surgery; Prognosis; Meta-analysis;

机译：大肠癌;转移;化学疗法;手术;预后;Meta分析;

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1. Is primary tumour resection associated with survival improvement in patients with colorectal cancer and unresectable synchronous metastases? A pooled analysis of individual data from four randomised trials [J] . Faron Matthieu, Pignon Jean-Pierre, Malka David, European journal of cancer: official journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR) . 2015,第2期

机译：大肠癌和无法切除的同步转移患者的原发肿瘤切除是否与生存改善相关？汇总来自四个随机试验的单个数据的分析
2. Resection of the primary tumour versus no resection prior to systemic therapy in patients with colon cancer and synchronous unresectable metastases (UICC stage IV): SYNCHRONOUS - a randomised controlled multicentre trial (ISRCTN30964555) [J] . Nuh N Rahbari, Florian Lordick, Christine Fink, BMC Cancer . 2012,第1期

机译：结肠癌合并同步性无法切除转移的患者（UICC IV期）的原发肿瘤切除与全身治疗前不切除的比较：SYNCHRONOUS-同步-一项随机对照多中心试验（ISRCTN30964555）
3. Impact of primary tumour resection on survival of patients with colorectal cancer and synchronous metastases treated by chemotherapy: Results from the multicenter, randomised trial Federation Francophone de Cancerologie Digestive 9601 [J] . F. Ferr, D. Malka, A. Bourredjem, European journal of cancer: official journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR) . 2013,第1期

机译：原发性肿瘤切除对化疗治疗结直肠癌和同步转移的患者的影响：多中心，随机试验联邦Francophone的结果Deancerologie Digestive 9601
4. High-Depth Sequencing of Over 750 Genes Supports Linear Progression of Primary Tumors and Metastases in the Majority of Patients with Liver-Limited Metastatic Colorectal Cancer [C] . Simeen Malik, Iain Beehuat Tan, Kalpana Ramnarayanan, International Molecular Medicine Tri-Conference. . 2015

机译：超过750个基因的高深度测序支持肝脏有限转移性结直肠癌大多数患者的原发性肿瘤和转移的线性进展
5. Differentiating synchronous second primary lung cancer from pulmonary metastases using clinicopathologic analysis and gentic profiling. [D] . Sayers, Brendan. 2011

机译：使用临床病理分析和基因谱分析将同期的第二原发性肺癌与肺转移瘤区分开来。
6. Resection of the primary tumour versus no resection prior to systemic therapy in patients with colon cancer and synchronous unresectable metastases (UICC stage IV): SYNCHRONOUS - a randomised controlled multicentre trial (ISRCTN30964555) [O] . Nuh N Rahbari, Florian Lordick, Christine Fink, 2012

机译：结肠癌合并同步性无法切除转移的患者（UICC IV期）的原发性肿瘤切除与全身性治疗前不切除的比较：SYNCHRONOUS-同步-一项随机对照的多中心试验（ISRCTN30964555）
7. Resection of the primary tumour versus no resection prior to systemic therapy in patients with colon cancer and synchronous unresectable metastases (UICC stage IV): SYNCHRONOUS - a randomised controlled multicentre trial (ISRCTN30964555) [O] . Nuh N Rahbari, Florian Lordick, Christine Fink, 2012

机译：结肠癌合并同步性无法切除转移的患者（UICC IV期）的原发肿瘤切除与全身治疗前不切除的比较：SYNCHRONOUS-同步-一项随机对照多中心试验（ISRCTN30964555）

Is primary tumour resection associated with survival improvement in patients with colorectal cancer and unresectable synchronous metastases? A pooled analysis of individual data from four randomised trials

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