Molecularly imprinted SPE combined with dispersive liquid-liquid microextraction for selective analysis of telmisartan in biological and formulation samples

摘要

Background: The present communication describes the combination of molecularly imprinted SPE and dispersive liquid-liquid microextraction for the selective preconcentration and determination of telmisartan (TEL) in rat urine, plasma and pharmaceutical formulation by HPLC. Results: Various factors that can affect the extraction efficiency of molecularly imprinted SPE and dispersive liquid-liquid microextraction were optimized. The LOD and LOQ were found to be 0.19 and 0.63 g ml-1 in urine, while in plasma it was found to be 0.28 and 0.87 g ml-1, respectively. The percentage recovery of TEL in different matrices was found to be in the range of 81-97%. Conclusion: The proposed method may find wide applications in clinical, toxicological and QC laboratories for the routine analysis of TEL.