Perivenous application of cyanoacrylate tissue sealants reduces intimal and medial thickening of the vein graft and inflammatory responses in a rabbit model of carotid artery bypass grafting

摘要

Effective therapies to prevent vein graft failure after coronary artery bypass grafting (CABG) are still lacking. alpha-Cyanoacrylate (alpha-CA, 99% n-octyl-alpha-cyanoacrylate + n-butyl-alpha-cyanoacrylate) has been increasingly used as a tissue sealant for wound closure because of its bacteriostatic, biodegradable and haemostatic properties. As a strong tissue adhesive, alpha-CA might prevent an arterial circulation-induced mechanical stretch on vein graft to attenuate intimal hyperplasia. Here, we investigated the effects of perivenous application of alpha-CA on the vein graft in a rabbit model of carotid artery bypass grafting.