Synthesis, anticancer activity and photostability of novel 3-ethyl-2-mercapto-thieno[2,3-d]pyrimidin-4(3H)-ones

Mavrova Anelia Ts; Dimov Stefan; Yancheva Denitsa; Rangelov Miroslav; Wesselinova Diana; Tsenov Jordan A.

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Synthesis, anticancer activity and photostability of novel 3-ethyl-2-mercapto-thieno[2,3-d]pyrimidin-4(3H)-ones

机译：新型3-乙基-2-巯基-硫代[2,3-d]嘧啶-4（3H）-ones的合成，抗癌活性和光稳定性

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摘要

Some derivatives of 3-ethyl-2-mercapto-thieno[2,3-d]pyrimidin-4(3H)-ones were synthesized using ethyl 2-aminothiophene-3-carboxylates as precursors in order to estimate their cytotoxicity, respectively proliferative activity.

机译：以2-氨基噻吩-3-羧酸乙酯为前体合成了3-乙基-2-巯基噻吩并[2,3-d]嘧啶-4（3H）-的一些衍生物，以评估其细胞毒性和增殖活性。

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《European Journal of Medicinal Chemistry: Chimie Therapeutique》 |2016年第null期|共11页
作者
Mavrova Anelia Ts; Dimov Stefan; Yancheva Denitsa; Rangelov Miroslav; Wesselinova Diana; Tsenov Jordan A.;
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正文语种 eng
中图分类药学;
关键词
Thieno2; 3-dpyrimidin-4(3H)-ones; DFT; Cytotoxicity; Photo stability; Anticancer activity; B-Raf;

机译：Thieno [2;3-d]嘧啶-4（3H）-ones;DFT;细胞毒性;光稳定性;抗癌活性;B-Raf;

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1. Synthesis, anticancer activity and photostability of novel 3-ethyl-2-mercapto-thieno[2,3-d]pyrimidin-4(3H)-ones [J] . Mavrova Anelia Ts, Dimov Stefan, Yancheva Denitsa, European Journal of Medicinal Chemistry: Chimie Therapeutique . 2016,第Null期

机译：新型3-乙基-2-巯基-硫代[2,3-d]嘧啶-4（3H）-ones的合成，抗癌活性和光稳定性
2. Anticancer Activity Evaluation of New Thieno[2,3-d]pyrimidin-4(3H)-ones and Thieno[3,2-d]pyrimidin-4(3H)-one Derivatives [J] . Olga Shyyka, Nazariy Pokhodylo, Nataliya Finiuk, Scientia pharmaceutica . 2018,第3期

机译：Thieno [2,3-d] pyrimidin-4（3H）-one和Thieno [3,2-d] pyrimidin-4（3H）-one衍生物的抗癌活性评估
3. SYNTHESIS AND ANALGESIC ACTIVITY OF 2-ARYLAMINO-3-ARYL-5-PHENYL-THIENO [2,3-d] PYRIMIDIN-4(3H)-ONES AND 2-ARYLAMINO-3-ARYL-7-PHENYL-THIENO [3,2-d] PYRIMIDIN-4(3H)-ONES [J] . Ishwarsinh S.Rathod, Harsha U.Patel Indian Journal of Heterocyclic Chemistry. (Text in English) . 2005,第3期

机译：2-ARYLAMINO-3-ARYL-5-PHENYL-THIENO [2,3-d] PYRIMIDIN-4（3H）-ones and 2-ARYLAMINO-3-ARYL-7-Phenyl-Thieno [3，3的合成和止痛活性[3， 2-d] PYRIMIDIN-4（3H）-ONES
4. Efficient Synthesis of Thieno 2,3-d Pyrimidin-4(4H)-ones by the Aza-Wittig Methodology [C] . Hong Chen, Kai Yan, Ming-Guo Liu SSITE International Conference on Future Material Research and Industry Application . 2012

机译：AZA-Wittig方法的高效合成Thieno 2,3-D嘧啶-4（4H） - 酮
5. Chemical Space Exploration Around Thieno[3,2-d]Pyrimidin-4(3H)-One Scaffold Led to a Novel Class of Highly Active Clostridium difficile Inhibitors [D] . Shao, Xuwei. 2020

机译：Thieno [3,2-D]嘧啶-4（3H）周围的化学空间探索-NE脚手架导致了一种新型高活性梭菌艰难梭菌抑制剂
6. Synthesis and biological evaluation of a series of 2-(((5-akly/aryl-1H-pyrazol-3-yl)methyl)thio)-5-alkyl-6-(cyclohexylmethyl)-pyrimidin-4(3H)-ones as potential HIV-1 inhibitors [O] . Yumeng Wu, Chengrun Tang, Ruomei Rui, 2020

机译：一系列2-（（（5-akly /芳基-1H-吡唑-3-基）甲基）硫基）-5-烷基-6-（环己基甲基）-嘧啶-4（3H）-的合成及生物评价作为潜在的HIV-1抑制剂
7. Efficient synthesis and fungicidal activities of 2-alkylamino-6-(1H-1,2,4-triazol-1-yl)-thieno[2,3-d]pyrimidin-4(3H)-ones [O] . Yong Sun, Jing Wu, Jian Wan, 2009

机译：2-烷基氨基-6-（1H-1,2,4-三唑-1-基） - 噻吩并[2,3-d]嘧啶-4（3H） - 酮的高效合成和杀菌活性

Synthesis, anticancer activity and photostability of novel 3-ethyl-2-mercapto-thieno[2,3-d]pyrimidin-4(3H)-ones

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