Synthesis, antiviral activity, and stability of nucleoside analogs containing tricyclic bases.

Amblard F; Fromentin E; Detorio M

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Synthesis, antiviral activity, and stability of nucleoside analogs containing tricyclic bases.

机译：含有三环碱基的核苷类似物的合成，抗病毒活性和稳定性。

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A series of 3,9-dihydro-9-oxo-5H-imidazo[1,2-A]purine nucleosides (tricylic nucleosides) were synthesized from 9-[4-alpha-(hydroxymethyl)cyclopent-2-ene-1-alpha-yl]guanine (CBV) 5, (-)-beta-D-(2R,4R)-1,3-dioxolane-guanosine (DXG) 6, 3'-azido-3'-deoxy-guanosine (AZG) 7, and 2'-C-methylguanosine 8. Their in vitro activity against HIV and HCV was evaluated and correlated to their ability to degrade to their purine counterpart.

机译：从9- [4-α-（羟甲基）环戊-2-烯-1-合成了一系列的3,9-二氢-9-氧代-5H-咪唑并[1,2-A]嘌呤核苷（三甲基核苷）。 α-基]鸟嘌呤（CBV）5，（-）-β-D-（2R，4R）-1,3-二氧戊环-鸟苷（DXG）6，3'-叠氮基3'-脱氧-鸟苷（AZG） 7和2'-C-甲基鸟嘌呤8.评价了它们对HIV和HCV的体外活性，并将其与降解为嘌呤的能力相关联。

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《European Journal of Medicinal Chemistry: Chimie Therapeutique》 |2009年第10期|共7页
作者
Amblard F; Fromentin E; Detorio M;
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正文语种 eng
中图分类医药、卫生;劳动卫生;
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1. Synthesis, antiviral activity, and stability of nucleoside analogs containing tricyclic bases. [J] . Amblard F, Fromentin E, Detorio M European Journal of Medicinal Chemistry: Chimie Therapeutique . 2009,第10期

机译：含有三环碱基的核苷类似物的合成，抗病毒活性和稳定性。
2. Synthesis and Antiviral Activity Evaluation of 2 ',5 ',5 '-Trifluoro-Apiosyl Nucleoside Phosphonic Acid Analogs [J] . Kim Eunae, Hong Joon Hee Nucleosides, nucleotides and nucleic acids . 2016,第1a3期

机译：2'，5'，5'-三氟-Apiosyl核苷磷酸类似物的合成及抗病毒活性评估
3. Design, synthesis, and antiviral activity of new 1H-1,2,3-triazole nucleoside ribavirin analogs [J] . Maria de Lourdes G. Ferreira, Luiz C. S. Pinheiro, Osvaldo A. Santos-Filho, Medicinal chemistry research: an international journal for rapid communications on design and mechanisms of action of biologically active agents . 2014,第3期

机译：新的1H-1,2,3-三唑核苷利巴韦林类似物的设计，合成和抗病毒活性
4. Structure-Cytotoxicity/Antiviral Activity Relationship Studies of Nucleoside Analogs Using Structure-Activity Maps [C] . Ravi R. Parakulam, Mathew L. Lesniewski, Michael A. Marquis II, AAAI Symposium . 1999

机译：结构 - 细胞毒性/抗病毒活性关系使用结构 - 活动图的核苷类似物的关系研究
5. Part I: Synthesis of Cyclobutyl Nucleoside Analogs That Mimic AZT for Inhibition of the K65R HIV-1 Reverse Transcriptase Mutant. Part II: Synthesis and Evaluation of Truncated Triptolide Analogs to Suppress Chronic Inflammation [D] . Bluemling, Gregory Richard 2011

机译：第一部分：模拟AZT抑制K65R HIV-1逆转录酶突变体的环丁基核苷类似物的合成。第二部分：截短雷公藤甲素类似物的合成和评估，以抑制慢性炎症
6. Synthesis antiviral activity and stability of nucleoside analogs containing tricyclic bases [O] . Franck Amblard, Emilie Fromentin, Mervi Detorio, -1

机译：含有三环基碱的核苷类似物的合成抗病毒活性和稳定性
7. Evaluation of carbodine, the carbocyclic analog of cytidine, and related carbocyclic analogs of pyrimidine nucleosides for antiviral activity against human influenza Type A viruses. [O] . Shannon, W M, Arnett, G, Westbrook, L, 1981

机译：评价卡博定，胞嘧啶核苷的碳环类似物以及嘧啶核苷的相关碳环类似物对人类甲型流感病毒的抗病毒活性。
8. Synthesis of Nucleoside Analogues with Potential Antiviral Activity against Negative Strand RNA Virus Targets. [R] . Walker, R. T. 1989

机译：具有抗负链RNa病毒靶标的潜在抗病毒活性的核苷类似物的合成。

Synthesis, antiviral activity, and stability of nucleoside analogs containing tricyclic bases.

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