Generalized eruption with histopathologic toxic epidermal necrolysis caused by occupational exposure to thiourea dioxide.

摘要

Occupational exposure to chemicals can cause severe cutaneous reactions similar to erythema multiforme (EM), Stevens-Johnson syndrome (SJS) or toxic epidermal necrolysis (TEN). We report an occupational dermatitis associated with thiourea dioxide, manifesting as histopath-ologic epidermal necrolysis.A 58-year-old man presented with generalized maculo-papular erythema and blisters, sparsely distributed on both arms, the trunk, right thigh and face, excluding the mucous membranes. The patient had worked in the textile spinning industry for over 30 years without experiencing anv skin problems.