Lichen planus-type ehronic graft-versushost disease complicated by mucous membrane pemphigoid with positive anti-BP180/230 and scleroderma-related autoantibodies followed by reduced regulatory T cell frequency

摘要

A 17-year-old Japanese man presented with recurrent oral aphtha and scaly erythemas on the trunk and extremities in October 2010. Peripheral blood stem cell transplantation (PBSCT) had been performed from human leukocyte antigen-identical unrelated donors 18 months before for his mixed lineage leukemia. One month after PBSCT, acute GVHD (aGVHD)-induced diarrhea developed and was improved by prednisolone (PSL), tacrolimus, and methotrexate (MTX). In October 2009, he presented with systemic scaly erythemas, diarrhea, and liver dysfunction (figure 1A).