Ultra Culture

摘要

Of the many analytical challenges facing researchers during the early development of Pharmaceuticals, the measurement of viscosity is especially important. Being able to accurately determine this can reduce the number of candidate failures during subsequent stages. Measuring viscosity during the preformulation development of Pharmaceuticals - particularly biopharmaceuticals - can be especially challenging. Researchers will be dealing with extremely small volumes of highly valuable samples, where measurement is needed under formulation conditions, often at high concentrations. Conventional techniques for measuring viscosity struggle under these circumstances. Coupled with this is the increasing demand for automated methodologies which can perform high throughput measurements of more than one parameter of the same small sample.This article describes the application of ultraviolet (UV) area imaging to automated viscosity and molecular size measurements for biological formulations, and its uses and advantages over conventional techniques.