首页> 外文期刊>European journal of human genetics: EJHG >A large-sample assessment of possible association between ischaemic stroke and rs12188950 in the PDE4D gene
【24h】

A large-sample assessment of possible association between ischaemic stroke and rs12188950 in the PDE4D gene

机译:大样本评估PDE4D基因中缺血性中风与rs12188950之间可能的关联

获取原文
获取原文并翻译 | 示例
           

摘要

Previous reports have shown ambiguous findings regarding the possible associations between ischaemic stroke (IS) and single nucleotide polymorphisms (SNPs) in the phosphodiesterase 4D (PDE4D) gene region. The SNP rs12188950 (or SNP45) has often been studied in this context. We performed a multi-centre study involving a large sample of 2599 IS patients and 2093 control subjects from the south and west regions of Sweden to replicate previous studies regarding IS risk and rs12188950. Subjects from Lund Stroke Register (LSR), Malm? Diet and Cancer Study (MDC) and Sahlgrenska Academy Study on Ischemic Stroke (SAHLSIS) were enroled. Subgroups of participants with hypertension and participants < 55 years of age, as well as the TOAST subgroups large vessel disease, small vessel disease and cardioembolism, were also assessed. Univariate odds ratios (ORs) and ORs controlling for hypertension, diabetes and current smoking were calculated. We additionally performed a meta-analysis including 10 500 patients and 10 102 control subjects from 17 publications (including the present study). When assessing pooled data from LSR, MDC and SAHLSIS we obtained no association between IS and rs12188950 for all participants (OR0.93; 95% confidence interval (CI): 0.83-1.05). Significant associations were not found for hypertensive participants or participants with age < 55, or when separately evaluating patients from the three different TOAST subgroups. The meta-analysis showed no significant overall estimate (OR0.96; 95% CI: 0.89-1.04) with significant heterogeneity for random effect (P=0.042). No effect from rs12188950 on IS was found from either our pooled multi-centre data or the performed meta-analysis. We did not find any association between the examined subgroups and rs12188950 either.
机译:先前的报告显示了关于缺血性中风(IS)和磷酸二酯酶4D(PDE4D)基因区域中的单核苷酸多态性(SNP)之间可能关联的模糊结论。在这种情况下,经常对SNP rs12188950(或SNP45)进行了研究。我们进行了一项多中心研究,涉及来自瑞典南部和西部地区的2599名IS患者和2093名对照受试者的大量样本,以复制以前有关IS风险和rs12188950的研究。马尔姆隆德卒中记录(LSR)的主题?参加了饮食和癌症研究(MDC)和萨尔格伦斯卡学院缺血性卒中研究(SAHLSIS)。还评估了高血压参与者和55岁以下参与者的亚组,以及TOAST的大血管疾病,小血管疾病和心脏栓塞亚组。计算出控制高血压,糖尿病和当前吸烟的单变量比值比(OR)和OR。我们还进行了荟萃分析,包括来自17种出版物(包括本研究)的10500名患者和10102名对照受试者。当评估来自LSR,MDC和SAHLSIS的汇总数据时,对于所有参与者,我们在IS和rs12188950之间均未发现关联(OR0.93; 95%置信区间(CI):0.83-1.05)。对于高血压受试者或年龄<55岁的受试者,或分别评估三个不同的TOAST亚组的患者时,未发现显着相关性。荟萃分析显示无显着总体估计(OR0.96; 95%CI:0.89-1.04),随机效应具有显着异质性(P = 0.042)。从我们汇总的多中心数据或进行的荟萃分析中均未发现rs12188950对IS的影响。我们也没有发现被检查的亚组和rs12188950之间有任何关联。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱:kefu@zhangqiaokeyan.com

京公网安备:11010802029741号 ICP备案号:京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有
  • 客服微信

  • 服务号