PRELIMINARY LABORATORY AND FIELD TRIALS ON THE EFFECTS OF ENDOD (PHYTOLACCA DODECANDRA) ON EPIZOOTIC LYMPHANGITIS

摘要

A study was conducted to determine the effect of Endod (Phytolacca dodecandra) on the growth of Histoplasma capsulatum var. farciminosum (HCF) on Sabouraud's dextrose agar and evaluate its therapeutic value on 52 cases of epizootic lymphangitis (EL).The study was carried out in three towns of central Ethiopia between December 2001 and June 2002. Clinical examination, differential white blood cell counts and bacteriology were used for the evaluation of response to treatment Sterilized Endod inhibitedthe growth of HCF at 1% (W/V). A highly significant (X~2 = 19.05; P<0.0001) difference to treatment was recorded between early and advanced cases. The differential white blood cell counts showed a progressive increase in the number of neutrophils in advanced cases while lymphocytes were observed to steadily increase in the early cases that responded to treatment. The results of the present study demonstrated that Endod inhibits growth of HCF on Sabouraud's dextrose agar.