Lymphomatoid granulomatosis developing from chronic active Epstein-Barr virus infection in a patient with myelodysplastic syndrome.

摘要

Chronic active Epstein-Barr virus (CAEBV) infection is rare and has a high morbidity and mortality rates from hepatic failure, lymphoma, sepsis, or hemophagocytic syndrome (1, 2). CAEBV infection often develops into natural killer (NK) or T-cell lymphoma and rarely progresses to B-cell malignancy (3, 4). Two cases of EBV-positive diffuse large B-cell lymphoma (EBV + DLBCL) were reported in a patient with leukemia and MDS (5, 6); however, the relation with CAEBV infection and DLBCL was still unclear and little is known yet about lymphomatoid granulomatosis (LYG) developing from CAEBV infection.