Low-power laser to prevent oral mucositis in autologous hematopoietic stem cell transplantation.

摘要

To the Editor,Oral mucositis is a frequent complication of hematopoi-etic stem cell transplantation (HSCT) (1, 2). Low power laser (LPL) has been tested in the prophylaxis and treatment of oral mucositis with promising results (1, 3, 4). In this study, the prophylactic effect of LPL was tested in a double-blind randomized placebo-controlled trial. Adult patients undergoing autologous HSCT from January 2005 to July 2006 were eligible, provided they had integrity of the oral mucosa, and good oral hygiene and dental status on admission. The protocol was approved by the Institution Ethics Committee and patients signed an informed consent. Patients received LPL or placebo with daily applications from D-7 to DO. LPL was applied bilaterally in the following anatomic sites: posterior wall of the oropharynx; buccal mucosa; hard and soft palate; dorsal, ventral and lateral sides of the tongue; floor of the mouth; upper and lower labial mucosa; and vermillion border.