Telaprevir-induced acute kidney injury during treatment of chronic hepatitis C

摘要

Telaprevir in combination with peginterferon and ribavir-in is one of the major treatments for chronic hepatitis C [1]. Although it shows distinguished efficacy, the incidence of severe adverse reactions is higher than for conventional therapy [2]. We report a case of acute kidney injury (AKI) that required intensive care caused by telaprevir-containing combination therapy for chronic hepatitis G. A 66-year-old woman was admitted for treatment of chronic hepatitis G. She had undergone a combination therapy with peginterferon and ribavirin at the age of 62 years following a relapse. Her body weight was 59 kg, and physical examination revealed no abnormality. Laboratory test on admission showed mildly elevated aminotransferase levels; the creatinine level was 0.64mg/dl and estimated glomerular filtration rate was 70.2 ml/min/ 1.73 m2. In a test for hepatitis C virus (HCV) RNA by the COBAS TaqMan HCV test (Roche Diagnostics, Tokyo, Japan), the HCV RNA level was found to be 6.9 IU/ml; the genotype was 1b.