...
首页> 外文期刊>European journal of gastroenterology and hepatology >Prospective pilot evaluation of a new needle prototype for endoscopic ultrasonography-guided fine-needle aspiration: comparison of cytology and histology yield.
【24h】

Prospective pilot evaluation of a new needle prototype for endoscopic ultrasonography-guided fine-needle aspiration: comparison of cytology and histology yield.

机译:内镜超声引导细针抽吸术的新针原型的前瞻性先导评估:细胞学和组织学产量的比较。

获取原文
获取原文并翻译 | 示例
   

获取外文期刊封面封底 >>

       

摘要

OBJECTIVES: Endoscopic ultrasonography (EUS) with the adjunct of EUS-guided fine needle aspiration has become an important diagnostic modality in gastroenterologic oncology. EUS-guided fine needle aspiration mainly relies on cytology; data are scarce that compare cytology and histology. While testing a 22-gauge prototype needle, we prospectively compared the yield for both. METHODS: Forty-two consecutive patients (27 male, 15 female; mean age 59.2 years, range: 17-90 years) were included. In each patient we aimed to make two needle passes, and if the material acquired appeared insufficient macroscopically (no in-room cytopathology was available), further passes were done. The material was sent for cytological and histological assessment. RESULTS: A median number of two passes (range: 2-3) were uneventfully performed for pancreatic lesions (n=30), mediastinal and other lymph nodes/masses (n=8) and various other lesions (n=4) and yielded adequate material for cytology, histology or at least one of the two investigations in 62, 67 and 74% of patients, respectively. No false positive results were found (specificity 100%). Sensitivities were 58.6 and 65.5%, respectively, for cytology and histology alone; combined assessment increased sensitivity to 79.3%. When adjusted values were calculated, based only on those cases with adequate material, sensitivity was 89.5% for cytology and 85.7% for histology, and increased to 100% with combined assessment. CONCLUSION: The new needle achieves sensitivities similar to those previously reported with no significant differences in sensitivity between cytology and histology. More effective tissue acquisition methods must be sought to improve overall results.
机译:目的:内镜超声检查(EUS)与EUS引导的细针抽吸术相辅相成已成为胃肠肿瘤学的重要诊断手段。 EUS指导的细针穿刺主要依靠细胞学检查。比较细胞学和组织学的数据很少。在测试22针原型针时,我们前瞻性地比较了两种针的产量。方法:纳入42例连续患者(男27例,女15例;平均年龄59.2岁,范围:17-90岁)。我们希望在每位患者中进行两次穿刺,如果从宏观上看,所获得的材料似乎不足(没有可用的室内细胞病理学),则需要进行进一步的穿刺。该材料已送去进行细胞学和组织学评估。结果:胰脏病变(n = 30),纵隔及其他淋巴结/肿块(n = 8)和其他各种病变(n = 4)平均进行了两次通过(范围:2-3),并产生了分别在62%,67%和74%的患者中进行细胞学,组织学检查或两次检查中的至少一项检查的足够材料。未发现假阳性结果(特异性100%)。仅细胞学和组织学的敏感性分别为58.6和65.5%;综合评估将敏感性提高到79.3%。当计算调整后的值时,仅基于那些具有足够材料的病例,细胞学敏感性为89.5%,组织学敏感性为85.7%,综合评估可提高到100%。结论:新针达到了与以前报道的相似的敏感性,细胞学和组织学之间的敏感性没有显着差异。必须寻求更有效的组织采集方法以改善总体效果。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱:kefu@zhangqiaokeyan.com

京公网安备:11010802029741号 ICP备案号:京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有
  • 客服微信

  • 服务号