Evidence of mechanism of action of antl-Inflammatory/antlnodceptive activities of acacetin

摘要

Background: Acacetin is a bioflavonoid with pharmacological properties such as antmociceptive/anti-inflammatory activities. However, scientific evidence of its spectrum activity and mechanisms of action is unknown. Methods: Acacetin administered via i.p. was assessed using several nociceptive experimental models such as the writhing test, the formalin test and carrageenan paw oedema in the thermal plantar tests (Hargreaves method) in mice, as well as the pain-induced functional impairment model in rat (PIFIR model).