【24h】

A review of diagnostic tests for congenital syphilis in newborns.

机译:新生儿先天性梅毒的诊断测试综述。

获取原文
获取原文并翻译 | 示例
       

摘要

Congenital syphilis (CS) can occur when a mother is inadequately treated or not treated at all for an active Treponema pallidum infection. Symptoms of CS are often subtle and non-specific, and it is estimated that up to 60% of affected infants are asymptomatic at birth, making the diagnosis dependent on laboratory findings. Despite decades of experience with CS, problems still arise in its diagnosis because laboratory test results for children at risk for CS can be inconclusive and no single diagnostic test can be used to diagnose CS. The development of diagnostic tests such as enzyme immunoassays, immunoblotting and polymerase chain reaction (PCR) has increased the sensitivity and specificity of diagnoses, but the detection of specific IgM is currently the most sensitive serological method, and the presence of specific IgM should be considered as evidence of a congenital T. pallidum infection. Suspected cases can also be confirmed or excluded by serial post-partum tests of antibody kinetics. The authors note strongly that it is considered unethical not to treat a baby at risk of contracting CS, even without a definitive diagnosis. In this review, we describe the various microbiological methods-and their shortcomings-used in the laboratory diagnosis of CS.
机译:当母亲因活动性梅毒螺旋体感染而未得到充分治疗或根本没有得到治疗时,会发生先天性梅毒(CS)。 CS的症状通常是细微的和非特异性的,据估计,多达60%的受影响婴儿在出生时是无症状的,因此诊断取决于实验室检查结果。尽管有数十年的CS经验,但由于存在CS危险的儿童的实验室测试结果尚无定论,并且不能使用任何诊断测试来诊断CS,因此其诊断仍会出现问题。诊断测试(例如酶免疫测定,免疫印迹和聚合酶链反应(PCR))的发展提高了诊断的敏感性和特异性,但是特异性IgM的检测是目前最敏感的血清学方法,应考虑存在特异性IgM作为先天性梅毒螺旋体感染的证据。可疑的病例也可以通过连续的产后抗体动力学试验来确认或排除。作者强烈指出,即使没有明确的诊断,不治疗有患CS风险的婴儿也是不道德的。在这篇综述中,我们描述了各种微生物学方法及其缺点,这些方法用于CS的实验室诊断。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱:kefu@zhangqiaokeyan.com

京公网安备:11010802029741号 ICP备案号:京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有
  • 客服微信

  • 服务号