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Methadone-induced Torsade de pointes after stopping lopinavir-ritonavir.

机译:停用洛匹那韦-利托那韦后,美沙酮引起的Torsade de Pointes病情恶化。

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摘要

Various drugs can cause prolongation of the QT interval in an ECG, and in rare cases this is followed by the development of potentially fatal Torsade de pointes (TdP) . Since 2001, reports to the drug authorities in Europe and the USA have raised concerns that methadone may prolong the QT interval and thereby cause fatal arrhythmias. QT prolongation induced by methadone is dose-dependent. Patients treated for opioid dependence with methadone often receive concomitant medications for psychiatric disorders and infections (e.g. HIV), which allows great potential for drug-drug interactions. Described here is a case in which interruption of antiretroviral treatment triggered TdP by elevating the level of methadone in the patient's blood.
机译:各种药物可导致ECG中QT间隔的延长,在极少数情况下,这会导致潜在致命的扭转性扭转型室速发作(TdP)。自2001年以来,在欧洲和美国的药物管理局的报告中,人们开始担心美沙酮可能会延长QT间隔时间,从而导致致命的心律失常。美沙酮诱导的QT延长是剂量依赖性的。用美沙酮治疗阿片类药物依赖的患者经常会接受精神病和感染(例如HIV)的伴随用药,这为药物与药物的相互作用提供了巨大潜力。此处描述的是一种情况,其中抗逆转录病毒治疗的中断通过升高患者血液中的美沙酮水平触发了TdP。

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