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首页> 外文期刊>Brachytherapy >Initial radiation experience evaluating early tolerance and toxicities in patients undergoing accelerated partial breast irradiation using the Contura Multi-Lumen Balloon breast brachytherapy catheter.
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Initial radiation experience evaluating early tolerance and toxicities in patients undergoing accelerated partial breast irradiation using the Contura Multi-Lumen Balloon breast brachytherapy catheter.

机译:使用Contura多腔气球乳房近距离放射治疗导管评估接受加速部分乳房照射的患者的早期耐受性和毒性的初步放射经验。

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PURPOSE: We reviewed our institution's experience treating patients with the Contura Multi-Lumen Balloon (SenoRx, Inc., Irvine, CA) breast brachytherapy catheter to deliver accelerated partial breast irradiation. METHODS AND MATERIALS: Forty-one patients treated with breast-conserving therapy received adjuvant radiation using the Contura catheter (34Gy in 3.4Gy fractions). Thirteen patients had Stage 0, 21 had Stage I, and 7 had Stage II breast cancer. Median followup was 8 months (range, 1-17). RESULTS: Median, minimum skin spacing was 10mm (range, 2-17). Median, maximum skin doses (% of prescribed dose [PD]) were 99.7 (range, 57.1-124.1). Eight patients were treated with a skin spacing
机译:目的:我们回顾了本机构使用Contura多腔气囊(SenoRx,Inc.,Irvine,CA)乳房近距离放射治疗导管治疗患者的经验,以提供加速的局部乳房照射。方法和材料:41例接受保乳治疗的患者使用Contura导管(34Gy,3.4Gy分数)接受了辅助放射。 13例0期患者,21例I期患者和7例II期乳腺癌。中位随访时间为8个月(范围1-17)。结果:中位数,最小皮肤间距为10mm(范围2-17)。最大皮肤剂量中位数(处方剂量[PD]的百分比)为99.7(范围57.1-124.1)。八名患者的皮肤间距小于或等于5mm,其中2个间距为2mm。最大肋骨剂量中位数为PD的102.6%(10.0-187.7),接受95%PD的评估计划目标体积(PTV_EVAL)的中位数百分比为98.8(范围79.4-107.4)。接受200%PD的中位数为5.7cc(范围1.3-9.9)。在6个月(n = 15)和12个月(n = 12)时具有出色/良好美容效果的患者百分比为100%。患者的耐受性以0-10级进行评估(0 =无疼痛,10 =需要麻醉性镇痛药)。在38位患者中,有37位在插入导管时疼痛等级≤3。发生了4例乳腺感染(11%)和1例短暂性症状性血清瘤。结论:使用Contura多腔球囊导管进行的辅助性局部乳房照射显示出与标准单腔球囊近距离放射疗法相似的毒性,并具有剂量学能力的提高(即减少了皮肤和肋骨的剂量并改善了PTV_EVAL的覆盖范围)。

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