Effect of an intravenous bolus of phenylephrine or ephedrine on skin blood flow during spinal anaesthesia: a randomised, double-blind, controlled study.

摘要

Ephedrine, a mixed a-adrenergic and (3-adrenergic agonist,1 and phenylephrine, a pure a-1-adrenergic agonist,2 are both effective in counteracting vasoplegia induced by spinal anaesthesia. Although changes in skin blood flow (SBF) induced by sympathetic blockade have been studied, the effects of these two vasopressors have not yet been described in the setting of spinal anaesthesiaWith Clinical Research Ethics Committee approval and written informed consent, 20 American Society of Anesthesiologists (ASA) status I-II adult patients scheduled for'elective surgery under spinal anaesthesia were enrolled in this prospective, randomised, double-blind study. Neurologic and cardiovascular diseases, diabetes, autonomic dysfunction, treatment with beta-blocking or vasoconstricting agents and pregnancy were all considered as exclusion criteria.