Methylating micronutrient supplementation during pregnancy influences foetal hepatic gene expression and IGF signalling and increases foetal weight

Oster M.; Nuchchanart W.; Trakooljul N.; Murani E.; Zeyner A.; Wirthgen E.; Hoeflich A.; Ponsuksili S.; Wimmers K.

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Methylating micronutrient supplementation during pregnancy influences foetal hepatic gene expression and IGF signalling and increases foetal weight

机译：妊娠期间补充甲基化微量营养素会影响胎儿肝基因表达和IGF信号传导并增加胎儿体重

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Purpose Maternal diet during pregnancy impacts foetal growth and development. In particular, dietary levels of methylating micronutrients (methionine, folate, choline, vitamins B6, and B12) interfere with the availability and allocation of methyl groups for methylation reactions, thereby influencing normal transcription. However, the currently recommended methylating micronutrient supplementation regimen is haphazard and arbitrary at best.

机译：目的孕妇在怀孕期间的饮食会影响胎儿的生长发育。特别是，饮食中甲基化微量营养素（蛋氨酸，叶酸，胆碱，维生素B6和B12）的水平会干扰甲基化反应的甲基的可用性和分配，从而影响正常转录。但是，目前推荐的甲基化微量营养素补充方案是随意的，而且充其量是任意的。

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《European journal of nutrition》 |2016年第4期|共11页
作者
Oster M.; Nuchchanart W.; Trakooljul N.; Murani E.; Zeyner A.; Wirthgen E.; Hoeflich A.; Ponsuksili S.; Wimmers K.;
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正文语种 eng
中图分类营养卫生、食品卫生;
关键词
Foetal programming; IGF system; Maternal diet; Methyl donors; One-carbon cycle; Pigs;

机译：胎儿编程;IGF系统;母亲饮食;甲基供体;一碳循环;猪;

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1. Methylating micronutrient supplementation during pregnancy influences foetal hepatic gene expression and IGF signalling and increases foetal weight [J] . Oster M., Nuchchanart W., Trakooljul N., European journal of nutrition . 2016,第4期

机译：妊娠期间补充甲基化微量营养素会影响胎儿肝基因表达和IGF信号传导并增加胎儿体重
2. Gene expression pattern of IGF2, PHLDA2, PEG10 and CDKN1C imprinted genes in spontaneous miscarriages or foetal deaths [J] . Epigenetics: official journal of the DNA Methylation Society . 2010,第5期

机译：IGF2，PHLDA2，PEG10和CDKN1C印迹基因在自然流产或胎儿死亡中的基因表达模式
3. Comment on: Nyirenda MJ, Dean S, Lyons V, Chapman KE, Seckl JR (2006) Prenatal programming of hepatocyte nuclear factor 4a in the rat: a key mechanism in the ‘foetal origins of hyperglycaemia’? Diabetologia 49: 1412–1420, and on: McCurdy CE, Friedman JE (2006) Early foetal programming of hepatic gluconeogenesis: glucocorticoids strike back. Diabetologia 49:1138–1141 [J] . S. P. Burns, R. D. Cohen Diabetologia . 2006,第11期

机译：评论：Nyirenda MJ，Dean S，Lyons V，Chapman KE，Seckl JR（2006年）大鼠肝细胞核因子4a的产前程序设计：“高血糖的胎儿起源”的关键机制是？ Diabetologia 49：1412-1420，以及之后：McCurdy CE，Friedman JE（2006）早期胎儿对肝糖异生的编程：糖皮质激素反冲。糖尿病49：1138–1141
4. Transient Exposition to Neonatal Hypothyroidism Increases Hepatic Gene Expression of Suppressors of Cytokine Signaling (SOCS) During Catch-Up Growth and in Adulthood [C] . Mirecki-Garrido M., Fernez-Perez L. European Congress of Pharmacology . 2012

机译：新生儿甲状腺功能减退症的瞬态阐述增加了在追赶生长和成年期间细胞因子信号传导（SOC）抑制剂的肝基因表达
5. Increased expression of regulator of G protein signaling 2 explains how choline supplementation increases visceral fat mass in phosphatidylethanolamine N-methyltransferase deficient mice. [D] . Li, Tete. 2011

机译：G蛋白信号转导因子2调节剂的表达增加解释了胆碱补充剂如何增加磷脂酰乙醇胺N-甲基转移酶缺陷型小鼠的内脏脂肪量。
6. Secular trends in pregnancy weight gain in German women and their influences on foetal outcome: a hospital-based study [O] . Nina Ferrari, Peter Mallmann, Konrad Brockmeier, 2014

机译：一项基于医院的研究表明德国女性的妊娠体重增长的长期趋势及其对胎儿结局的影响
7. Six practical diets were formulated to contain 2.6 (the basal diet), 48.9, 95.5, 189.83, 382.4, 779.53 mg/kg vitamin C diet. After 8 weeks of feeding, growth performance, antioxidant status, and innate immunity of juvenile pufferfish were analyzed. Results showed that specific growth rate and protein efficiency ratio in fish fed diets supplemented with vitamin C were significantly higher than in fish fed the control diet. Dietary vitamin C significantly up-regulated the expression levels of growth hormone receptors and Insulin-like growth factor. Blood cell numbers and respiratory burst activity were enhanced in fish fed vitamin C diet. Serum alkaline phosphatase, glutamic-pyruvic transaminase, and glutamic-oxaloacetic transaminase activity were significantly influenced by the dietary vitamin C levels. Fish fed diets supplemented with vitamin C showed increased hepatic superoxide dismutase, glutathione peroxidase, and catalase activity, but decreased malondialdehyde activity. In addition, we found that dietary vitamin C can significantly up-regulate the expression levels of immune-related genes (HSP70, HSP90, BAFF, TNF-α and IL-6) in liver. These results indicate that dietary vitamin C can significantly influence growth performance, antioxidant status, and innate immunity of pufferfish. [O] . Cheng C-H, Liang H-Y., Guo Z-X., 2017

机译：配制了六种实用饮食，分别含有2.6（基础饮食），48.9、95.5、189.83、382.4、779.53 mg / kg维生素C饮食。喂食8周后，分析了幼崽河豚的生长性能，抗氧化剂状态和先天免疫力。结果表明，补充维生素C的鱼饲料的比生长速率和蛋白质效率比显着高于对照组的鱼。饮食中的维生素C显着上调了生长激素受体和胰岛素样生长因子的表达水平。喂鱼的维生素C饮食可提高血细胞数量和呼吸爆发活性。饮食中的维生素C水平显着影响血清碱性磷酸酶，谷氨酸-丙酮酸转氨酶和谷氨酸-草酰乙酸转氨酶的活性。补充维生素C的鱼饲料日粮中肝超氧化物歧化酶，谷胱甘肽过氧化物酶和过氧化氢酶活性增加，但丙二醛活性降低。此外，我们发现饮食中的维生素C可以显着上调肝脏中免疫相关基因（HSP70，HSP90，BAFF，TNF-α和IL-6）的表达水平。这些结果表明，饮食中的维生素C可以显着影响河豚的生长性能，抗氧化状态和先天免疫力。

Methylating micronutrient supplementation during pregnancy influences foetal hepatic gene expression and IGF signalling and increases foetal weight

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