Investigation of vitamin B-6 inadequacy, induced by exposure to the anti-B-6 factor 1-amino d-proline, on plasma lipophilic metabolites of rats: a metabolomics approach

摘要

Vitamin B-6 status in the body is affected by several factors including dietary supply of the antivitamin B-6 factor, 1-amino d-proline (1ADP), which is present in flaxseed. Owing to the prevalence of moderate B-6 deficiency in the general population, a co-occurrence of 1ADP may lead to a further deterioration of B-6 status. To this end, we applied a nontargeted metabolomics approach to identify potential plasma lipophilic biomarkers of deleterious effect of 1ADP on moderately vitamin B-6-deficient rats using a high-performance liquid chromatography/quadrupole time-of-flight mass spectrometry.