High-fructose corn syrup-induced hepatic dysfunction in rats: improving effect of resveratrol

Sadi Gokhan; Ergin Volkan; Yilmaz Guldal; Pektas M. Bilgehan; Yildirim O. Gokhan; Menevse Adnan; Akar Fatma

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High-fructose corn syrup-induced hepatic dysfunction in rats: improving effect of resveratrol

机译：高果糖玉米糖浆诱导的大鼠肝功能异常：白藜芦醇的改善作用

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The increased consumption of high-fructose corn syrup (HFCS) may contribute to the worldwide epidemic of fatty liver. In this study, we have investigated whether HFCS intake (20 % beverages) influences lipid synthesis and accumulation in conjunction with insulin receptor substrate-1/2 (IRS-1; IRS-2), endothelial nitric oxide synthase (eNOS), sirtuin 1 (SIRT1) and inducible NOS (iNOS) expressions in liver of rats. Resveratrol was tested for its potential efficacy on changes induced by HFCS.

机译：高果糖玉米糖浆（HFCS）消耗量的增加可能导致全世界脂肪肝的流行。在这项研究中，我们调查了是否摄入HFCS（20％饮料）与胰岛素受体底物1/2（IRS-1; IRS-2），内皮型一氧化氮合酶（eNOS），sirtuin 1一起影响脂质的合成和积累。（SIRT1）和诱导型NOS（iNOS）在大鼠肝脏中的表达。测试了白藜芦醇对由HFCS引起的变化的潜在功效。

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《European journal of nutrition》 |2015年第6期|共10页
作者
Sadi Gokhan; Ergin Volkan; Yilmaz Guldal; Pektas M. Bilgehan; Yildirim O. Gokhan; Menevse Adnan; Akar Fatma;
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正文语种 eng
中图分类营养卫生、食品卫生;
关键词
High-fructose corn syrup; Resveratrol; Hepatic lipid; FASN; SREBP-1c; IRS-1; eNOS; SIRT1;

机译：高果糖玉米糖浆;白藜芦醇;肝脂质;FASN;SREBP-1c;IRS-1;eNOS;SIRT1;

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1. High-fructose corn syrup-induced hepatic dysfunction in rats: improving effect of resveratrol [J] . Sadi Gokhan, Ergin Volkan, Yilmaz Guldal, European journal of nutrition . 2015,第6期

机译：高果糖玉米糖浆诱导的大鼠肝功能异常：白藜芦醇的改善作用
2. High-fructose corn syrup causes vascular dysfunction associated with metabolic disturbance in rats: Protective effect of resveratrol [J] . AkarF., Uluda?O., AydinA., Food and Chemical Toxicology: An International Journal Published for the British Industrial Biological Research . 2012,第6期

机译：高果糖玉米糖浆引起大鼠代谢紊乱相关的血管功能障碍：白藜芦醇的保护作用
3. Resveratrol improves intrahepatic endothelial dysfunction and reduces hepatic fibrosis and portal pressure in cirrhotic rats [J] . DiPascoliM., DivíM., Rodríguez-VilarruplaA., Journal of Hepatology: The Journal of the European Association for the Study of the Liver . 2013,第5期

机译：白藜芦醇改善肝硬化大鼠肝内内皮功能障碍并降低肝纤维化和门脉压力
4. Analysis of α-dicarbonyl process contaminants in high-fructose corn syrup and carbonated soft drinks by UHPLC-DAD-ESI-MS/MS [C] . Sabrina Gensberger, Monika Pischetsrieder American Society for Mass Spectrometry Conference on Mass Spectrometry and Allied Topics . 2013

机译：UHPLC-DAD-ESI-MS / MS的高果糖玉米糖浆和碳酸软饮料中α-二羰基工艺污染物的分析
5. Oxidative Stress and Proteomic Studies of Mammalian Models of Age-Related Metabolic Dysfunction in Neurodegenerative Disorders: (1) Upregulation of Pin1 in Alzheimer Mouse Model (2) Analysis of Brain Post-Intranasal Administration of Insulin in Alzheimer and Induced Diabetic Mouse Models (3) Analysis Of Proteome Changes In The Parietal Lobule Of Rhesus Monkey Non-Human Primate Following Resveratrol Supplementation as a Part of a Western-Diet. [D] . Swomley, Aaron Michael. 2017

机译：氧化应激和蛋白质组学研究的神经退行性疾病的年龄相关代谢功能障碍的哺乳动物模型：（1）阿尔茨海默病小鼠模型中Pin1的上调（2）鼻内注射胰岛素对老年性痴呆症小鼠和诱导的糖尿病小鼠模型的分析（3）白藜芦醇补充作为西方饮食的一部分，恒河猴非人类灵长类动物顶叶小叶蛋白质组变化的分析。
6. Lactoferrin Dampens High-Fructose Corn Syrup-Induced Hepatic Manifestations of the Metabolic Syndrome in a Murine Model [O] . Yi-Chieh Li, Chang-Chi Hsieh -1

机译：乳铁蛋白抑制高果糖玉米糖浆诱导的小鼠代谢综合征的肝表现。
7. Lactoferrin dampens high-fructose corn syrup-induced hepatic manifestations of the metabolic syndrome in a murine model. [O] . Yi-Chieh Li, Chang-Chi Hsieh 2014

机译：乳铁蛋白在小鼠模型中抑制高果糖玉米糖浆诱导的代谢综合征的肝脏表现。

High-fructose corn syrup-induced hepatic dysfunction in rats: improving effect of resveratrol

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