Adverse left ventricular remodelling after acute myocardial infarction: Is there a simple treatment that really works?

摘要

Acute myocardial infarction (AMI), with its accompanying adverse sequelae, remains one of the most common causes of morbidity and mortality in the world. Following AMI and secondary to the loss of functional myocardium, the heart undergoes adaptive responses in an attempt to maintain the same cardiac output. The physical changes to the heart that occur as a result of these responses is termed remodelling. This remodelling begins immediately after AMI and may continue for a lifetime. While this adaptive remodelling may be beneficial in the short term, overtime it becomes deleterious, leading eventually to congestive heart failure.