Searching sequence Space - Using recombination to search more efficiently and thoroughly instead of making bigger combinatorial libraries

摘要

The rational design of proteins is performed by computer modeling of individual changes, fbl-lowed by time-consuming construction of the molecule, and then testing and evaluation. This iterative approach seeks to design proteins for specific tasks bydrawing correlations between amino acid sequence and specific shapes At its root, it is the attempt to understand an extremely complex system through its topography.