structural and Functional epitopes in the Growth Hormone Receptor Complex - Can information from large molecules lead to the design of small molecule mimetics?

摘要

Since human growth hormone has been cloned, expressed, bottled, and sold by Genentech (S, San Francisco, CA)--what more can be done with it? - -From the perspective in our laboratory, there's a lot that can still be done with this hormone First, we would like to understand the molecular basis of growth hormone's pharmacology This is very complicated because growth hormone has a variety of effects--many of which are mediated by its interactions with receptors other than the growth hormone receptors. We want to understand the molecular basis for these interactions, We feel that by understanding the interaction between a hormone and its receptor at a high-resolution structural level, we might begin to understand the kind of functional chemistry that hoimones use to interact with their receptors.