A ONE-POT FOUR-COMPONENT PROCEDURE FOR THE SYNTHESIS OF DISPIROTETRAHYDROQUINOLINE-BIS(2,2-DIMETHYL-1,3-DIOXANE-4,6-DIONE) DERIVATIVES

摘要

A simple and efficient procedure for the diastereoselective synthesis of dispiro tetrahydroquinoline-bis (2,2-dimethyl-1,3-dioxane-4,6-dione) derivatives through one-pot four-component reaction of aromatic aldehydes, 2,2-dimethyl-1,3-dioxane-4,6-dione, arylamines and acetone in the presence of potassium dihydrogen phosphate (KDP) is described. The procedure involves initial Knoevenagel reaction, followed by Diels-Alder, Michael additon and intramolecular reactions. The main advantages of the protocol are the high isolated yields, broad substrate scope, mild conditions, and easy operation.