首页> 外文期刊>EuroIntervention: journal of EuroPCR in collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology >Relation of angiographic side branch calibre to myocardial mass: A proof of concept myocardial infarct index
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Relation of angiographic side branch calibre to myocardial mass: A proof of concept myocardial infarct index

机译:血管造影侧支径与心肌质量的关系:概念性心肌梗死指数的证明

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摘要

Elevation of biomarkers and ischaemia after coronary stenting of a bifurcation is not uncommon due to side branch (SB) occlusion. Hence, it is important to understand the relation between the lumen calibre of the SB and the myocardial mass affected. The objective of this proof of concept perspective is to provide a formulation for the relation between the SB calibre and perfused myocardial mass based on experimentally-validated scaling laws. A lumen calibre-mass scaling law provides a nearly linear relation between cross-sectional area of SB and the myocardial mass at risk. It is clinically known that the larger the diameter of the SB the more myocardial mass is at risk. The present analysis formulates this notion quantitatively and provides a simple relation where the %infarct can be determined directly from the angiographic cross-sectional area of SB. This relation can help guide the decision for bifurcation stenting where the SB may be at risk for occlusion. This brief proof of concept perspective provides a basis for future human studies that may demarcate the calibre (and hence myocardial mass) in relation to cardiac biomarkers as a cut-off for treatment of SB.
机译:由于侧支(SB)闭塞,在分叉的冠状动脉支架置入术后,生物标志物和局部缺血的升高并不少见。因此,重要的是要了解SB的管腔口径与受影响的心肌质量之间的关系。此概念验证的目的是根据实验验证的定标定律,为SB口径与灌注心肌质量之间的关系提供一个公式。管腔质量定标定律提供了SB的横截面积与处于危险状态的心肌质量之间的近似线性关系。临床上已知SB的直径越大,心肌的危险就越大。本分析定量地提出了该概念,并提供了一种简单的关系,其中可以从SB的血管造影横截面面积直接确定梗死百分比。这种关系可以帮助指导分叉支架置入的决策,此时SB可能有阻塞的危险。这种简短的概念验证观点为将来的人类研究提供了基础,这些研究可能将与心脏生物标志物有关的口径(因此,心肌质量)划定为SB治疗的临界值。

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