Analgesics during pregnancy and cryptorchidism: additional analyses.

摘要

In 2010, we reported higher risk of cryp-torchidism among boys prenatally exposed to maternal use of acetaminophen. Another paper was published shortly thereafter also showing associations of prenatal exposure to the cyclooxygenase (COX) inhibitors, acetaminophen, acetyl-salicylic acid, and ibuprofen with cryp-torchidism in boys. Experimental data showed reduced testicular prostaglandin and testosterone production and reduced anogenital distance in prenatally exposed rats. Increased apoptosis in testis tissue and reduced testosterone levels in serum from experimental cryptorchid mice exposed to COX-2 inhibitors have also been reported. Yet another study has demonstrated that weak analgesic COX inhibitors alongside numerous environmental contaminants inhibit prostaglandin synthesis in mouse Sertoli cells and in fetal rat testes.