Benign focal epilepsies of childhood: genetically determined pathophysiology--epilepsy that comes and goes.

摘要

Developmental processes; the types of neuron expressing particular gene products; the sites of these receptors/channels, transporters, etc., on neurons and in circuits; and compensatory processes such as activation of other genes, sprouting, pruning, and receptor plasticity will determine the nature of the epileptic phenotype induced by a particular genetic alteration, and the ultimate functional outcome.