Molecular characterization of the interaction of crotamine-derived nucleolar targeting peptides with lipid membranes

摘要

A novel class of cell-penetrating, nucleolar-targeting peptides (NrTPs), was recently developed from the rattlesnake venom toxin crotamine. Based on the intrinsic fluorescence of tyrosine or tryptophan residues, the partition of NrTPs and crotamine to membranes with variable lipid compositions was studied. Partition coefficient values (in the 10~2-10~5 range) followed essentially the compositional trend POPC:POPG<=POPG