Influence of Central Neurotransmitters on Heart Rate Variability in Outbred Rats at Rest and during Acute Stress:Nature of Very-Low-Wave Spectrum Component Revisited

摘要

We studied the effect of blockade of neurotransmitter monoamine reuptake and inhibition of catecholamine synthesis on heart rate variability in outbred albino rats at rest and during acute stress. Amitriptyline increased, while a-methyltyrosine reduced the power of VLF waves in heart rate variability spectrum. The effect of amitriptyline manifested at rest and was most striking under stressful conditions, while the effect of a-methyltyrosine was observed only under conditions of acute stress. This suggests that VLF-band waves in the heart rate variability spectrum have catecholaminergic nature and are determined by activity of the central monoaminergic systems; the role of peripheral adrenergic influences mediated by humoral and nervous regulation in the formation of these waves cannot also be excluded.