Biocatalytic reduction of aromatic ketones with the aid of electrochemical regeneration of the coenzyme

摘要

Halogenated aromatic ketones were reduced electrochemically using dried cell of Geotrichum candidum as a catalyst with high enantioselectivity. Enzymes in the dried cell catalyzed both reactions to reduce substrates and to recycle the coenzyme using electric power, so any additional enzyme or co-substrate for coenzyme recycling was not necessary.