This special issue of Endocrine Pathology, together with a parallel issue of Hormone Metabolic Research compiles state-of-the-art reviews and selected original research findings presented at the September 2011 International Symposium on Pheochromocytoma and Paraganglioma (ISP 2011) [1-17]. This symposium, hosted by Pierre-Francois Plouin and Anne-Paule Gimenez-Roqueplo in Paris, France, attracted a record number of participants following ISP 2008 in Cambridge, UK and ISP 2005 in Bethesda, MD, USA. These symposia are multidisciplinary gatherings of physicians and basic scientists intended to rapidly advance understanding and treatment of pheochromocytoma and extra-adrenal paraganglioma. They are held under the aegis of the Pheochromocytoma and paraganglioma RESearch Support ORganization (PRESSOR, http://www.pressor.org), which was established in the Spring of 2004 following a 2003 workshop at Cold Spring Harbor organized by James Watson and William M Manger.
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