Synthesis of a novel beta-cyclodextrin derivative with high solubility and the electrochemical properties of ferrocene-carbonyl-beta-cyclodextrin inclusion complex as an electron transfer mediator

摘要

A facile strategy for preparing water-soluble beta-cyclodextrin derivative, carbonyl-beta-cyclodextrin, was developed by partial oxidation of beta-cyclodextrin. The solubility of carbonyl-beta-cyclodextrin was greatly enhanced due to the breaking of intramolecular hydrogen bond network of beta-cyclodextrin. Ferrocene was included into the cavity of carbonyl-beta-cyclodextrin to form Fc-carbonyl-beta-cyclodextrin inclusion complex. The electrochemical properties of Fc-carbonyl-beta-cyclodextrin were studied. The Fc-carbonyl-beta-cyclodextrin complex exhibited high solubility and was shown to be good electrochemical probe and efficient mediator for bioelectrocatalysis of glucose oxidase. The bioelectrocatalytic efficacy of Fc-carbonyl-beta-cyclodextrin complex opened up homogeneous applications of ferrocene in amperometric biosensor systems. (c) 2008 Elsevier B.V. All rights reserved.