Efficiency and Tolerance of Aranose Combinations with Cisplatin and Gemcitabine in Experimental Lung Cancer

摘要

The efficiency of aranose combinations with gemcitabine and cisplatin was studied in experimental Lewis lung epidermoid carcinoma. Significant synergism of all the studied combinations and their satisfactory tolerance was demonstrated. The gemcitabine+cisplatin+aranose combination was significantly more effective than gemcitabine+cisplatin.The search for new drug combinations is one of approaches to improving the efficiency of chemotherapy of small-cell and non-small-cell lung cancer. Effective drugs for lung cancer are platinum compounds, gemcitabine (G), and nitrosourea derivatives. The efficiency of gemcitabine+cisplatin (GP) combination characterized by a synergistic effect was demonstrated for experimental lung cancer [5,6].