Expression of Adhesion Molecules and Cyclin D1 in Cells of Solid-Pseudopapillary Tumors of the Pancreas

摘要

Disturbances in the expression of cell adhesion molecules in solid-pseudopapillary tumor cells were detected by immunohistochemical methods. Positive reaction to E-cadherin, catenins, and overexpression of cyclin Dl were found; these changes reflect peculiarities of morphological structure and biological behavior of the studied neoplasms.Solid pseudopapillary tumors (CPPT) of the pancreas are considered to be rare neoplasms with unknown histogenesis. These neoplasms usually appear in young women and are characterized by relatively favorable prognosis [1,8]. According to current views, cell adhesion disorders and Wnt-signal pathway activation play a great role in oncogenesis of various tumors [6,14]. Here we studied expression of E-cadherin, catenin, and cyclin Dl in SPPT.