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Direct evaluation of drug resistance parameters in gonococcus

机译:直接评估淋球菌的耐药性参数

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摘要

We carried out complex genetic analysis of clinical samples containing N. gonorrhoeae DNA, the genotype and profile of drug resistance of this agent were evaluated. Changes in genes responsible for the formation of N. gonorrhoeae resistance to penicillins, fluoroquinolones, and spectinomycin were detected during minisequencing with subsequent MALDI-TOF mass spectrometry. The sensitivity of gonococcus was evaluated directly in the clinical sample without culturing.
机译:我们对含有淋病奈瑟氏球菌DNA的临床样品进行了复杂的遗传分析,评估了该药物的基因型和耐药性。在随后进行的MALDI-TOF质谱分析中,检测到了导致淋病奈瑟菌对青霉素,氟喹诺酮和壮观霉素产生抗性的基因的变化。无需培养即可直接在临床样品中评估淋球菌的敏感性。

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