Simultaneous Square-Wave Voltammetric Determination of Paracetamol, Caffeine and Orphenadrine in Pharmaceutical Formulations Using a Cathodically Pretreated Boron-Doped Diamond Electrode

摘要

An electroanalytical method for the simultaneous determination of paracetamol (PAR), caffeine (CAF), and orphenadrine (ORPH) using the square-wave voltammetry (SWV) and a cathodically pretreated boron-doped diamond electrode was developed. The method exhibits linear responses to PAR, CAF, and ORPH in the concentration ranges 5.4×10~(-7)-6.1×10~(-5) M, 7.8×10~(-7)-3.5×10~(-5) M, and 7.8×10~(-7)-3.5×10~(-5) M, respectively, with detection limits of 2.3×10~(-7) M, 9.6×10~(-8) M, and 8.4×10~(-8) M, respectively. The proposed method was successfully applied in the simultaneous determination of these analytes in pharmaceutical formulations.