Hypertension has emerged as a dominant cardiovascular risk factor and cause of cardiovascular disease in most of the world. Effective reduction of high blood pressure, "control of hypertension," for prevention of future cardiovascular disease is now the main component of prevention for adult populations in both developed and developing nations. The worldwide epidemic of hypertension has prompted public health initiatives and simplified approaches, such as the polypill therapy or attempts to reduce salt intake. These are macrotherapies that are directed to large populations.
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