Effect of Zinc Chloride on Picrotoxin-Induced Hyperkinesis Depends on Its Concentration in Solution Injected into Rat Neostriatum

摘要

The hyperkinekic effect (increase in spontaneous activity and development of choreomyo-clonic hyperkinesis of the extremities and body) of picrotoxin injected into the rostral neostriatum of rats in a dose of 2 mug was reduced if the drug was injected together with ZnC_2 in a concentration of 0.1 mug/mul. ZnCl_2 in a concentration of 1 mug/mul did not modulate the effects of picrotoxin, while in a concentration of 3 mug/mul it increased spontaneous motor activity in the open field test without affecting the symptoms of choreomyoclonic hyperkinesis.