Immune Response of Submissive and Aggressive Mice under Conditions of Opioid Receptor Activation

摘要

Experiments on the model of paired sensory contact demonstrated that stimulation of immune response in aggressive CBA and C57B1/6J mice with 10- and 20-day experience of victories, respectively, was prevented by selective delta_2-opioid receptor agonists DSLET and kappa-opioid receptor agonists rimorphin in a dose of 100 mug/kg. In C57B1/6J mice with depression-like behavior, normalization (but not suppression) of the immune response under conditions of mu-opioid receptor stimulation (100 mug/kg) was observed. Selective modulation of activity of a certain type of opioid receptors can normalize the immune function modified during the formation of a certain behavioral type.