Effect of Glucocorticoid Receptor Blockade on Analgesic Effect of Corticotropin-Releasing Factor

N. I. Yarushkina; T. R. Bagaeva; L. P. Filaretova

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Effect of Glucocorticoid Receptor Blockade on Analgesic Effect of Corticotropin-Releasing Factor

机译：糖皮质激素受体阻滞剂对促肾上腺皮质激素释放因子镇痛作用的影响

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摘要

The role of glucocorticoid receptors in the analgesic effect of corticotropin-releasing factor in rats was studied after glucocorticoid receptor blockade with antagonist RU 38486. Glucocorticoid hormones can potentiate the analgesic effect of corticotropin-releasing factor or modulate the mechanisms of this effect, which depends on the type of painful stimulus.

机译：在用拮抗剂RU 38486阻断糖皮质激素受体后，研究了糖皮质激素受体在大鼠促肾上腺皮质激素释放因子的镇痛作用中的作用。糖皮质激素激素可以增强促肾上腺皮质激素释放因子的镇痛作用或调节其作用机制，这取决于痛苦刺激的类型。

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《Bulletin of experimental biology and medicine 》 |2011年第5期| 共4页
作者
N. I. Yarushkina; T. R. Bagaeva; L. P. Filaretova;
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正文语种 eng
中图分类基础医学 ;
关键词
corticotropin-releasing factor; corticosterone; glucocorticoid receptors; pain sensitivity; rats;

机译：促肾上腺皮质激素释放因子;皮质酮;糖皮质激素受体;疼痛敏感性;大鼠;

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1. Effect of Glucocorticoid Receptor Blockade on Analgesic Effect of Corticotropin-Releasing Factor [J] . N. I. Yarushkina, T. R. Bagaeva, L. P. Filaretova Bulletin of experimental biology and medicine . 2011 ,第5期

机译：糖皮质激素受体阻滞剂对促肾上腺皮质激素释放因子镇痛作用的影响
2. Analgesic Actions of Corticotropin-Releasing Factor (CRF)on Somatic Pain Sensitivity: Involvement of Glucocorticoid and CRF-2 Receptors [J] . N. I. Yarushkina, T. R. Bagaeva, L. P. Filaretova Neuroscience and behavioral physiology . 2009 ,第9期

机译：促肾上腺皮质激素释放因子（CRF）对躯体疼痛敏感性的镇痛作用：糖皮质激素和CRF-2受体的参与。
3. Blocking corticotropin-releasing factor-2 receptors, but not corticotropin-releasing factor-1 receptors or glucocorticoid feedback, disrupts the development of conditioned defeat. [J] . Cooper MA, Huhman KL Physiology & behavior . 2010 ,第4期

机译：阻断促肾上腺皮质激素释放因子2受体，但不阻断促肾上腺皮质激素释放因子1受体或糖皮质激素反馈，会破坏条件性失败的发生。
4. The Three-Dimensional Structure of the N-Terminal Domain of Corticotropin-Releasing Factor Receptors:Sushi Domains and the B1 Family of G Protein—Coupled Receptors [C] . MARILYN H. PERRIN, CHRISTY R. R. GRACE, ROLAND RIEK, International Symposium on VIP, PACAP, and Related Peptides . 2006

机译：皮质激素释放因子受体N-末端结构域的三维结构：寿司结构域和B1蛋白偶联受体的B1系列
5. Characterization of a Novel, Stress-Responsive Sexually Dimorphic Corticotropin-Releasing Factor Receptor 1 (CRFR1) Nucleus in the Rostral Anteroventral Periventricular Nucleus of the Mouse [D] . Rosinger, Zachary J. 2019

机译：小鼠鼻腔胎腔靶细胞核中新型，响应性响应性二晶皮质甾醇释放因子受体1（CRFR1）核的表征
6. Blocking corticotropin-releasing factor-2 receptors but not corticotropin-releasing factor-1 receptors or glucocorticoid feedback disrupts the development of conditioned defeat [O] . Matthew A. Cooper, Kim L. Huhman -1

机译：阻断皮质皮蛋白释放因子-2受体但不是皮质科醛释放因子-1受体或糖皮质激素反馈破坏了条件失败的发展
7. Region-specific alterations in the corticotropin-releasing factor and glucocorticoid receptors in the postmortem brain of suicide victims [O] . Ghanshyam N. Pandey 2012

机译：自杀受害者死后大脑中促肾上腺皮质激素释放因子和糖皮质激素受体的区域特异性变化

Effect of Glucocorticoid Receptor Blockade on Analgesic Effect of Corticotropin-Releasing Factor

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