Cellular Expression of INK4a Gene in Cells of Bladder Cancer Associated with Human Papilloma Virus-16

摘要

Hyperexpression of pl6~(INK4a) protein is an early marker of cervical cancer. Hyperexpression of INK4a gene encoding this protein at the level of mRNA and pl6~(INK4a) was detected in tumor cells of some patients with bladder cancer associated with human papilloma virus-16. However, in contrast to cervical cancer, this phenomenon in urothelial carcinomas does not correlate with expression of human papilloma virus-16 oncogenes E6 and E7.