Variability of neuronal damage and proportion of activities of NO synthase isoforms during cerebral ischemia/reperfusion in rats

摘要

We studied expression of endothelial and neuronal NO synthase isoforms and severity of ischemia/reperfusion-induced damage to neurons in different brain compartments in albino rats. The peculiarities of distribution of NO synthase isoforms in the cerebral cortex and medulla oblongata were determined by different sensitivity of these compartments to ischemic and reperfusion damage to neurons.