首页> 外文期刊>Bulletin of experimental biology and medicine >Changes in the Blood Lipid-Transporting System in Rats over the First Day of Experimental Peritonitis.
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Changes in the Blood Lipid-Transporting System in Rats over the First Day of Experimental Peritonitis.

机译:实验性腹膜炎的第一天,大鼠的血脂运输系统发生了变化。

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摘要

Changes in the lipid spectrum of blood plasma and composition of high-density lipoproteins in outbred albino rats were studied during early stages of experimental peritonitis. We revealed an increase in lecithin:cholesterol acyltransferase activity, activation of lipolytic production of high-density lipoproteins from very-low-density lipoproteins, and substitution of arachidonic acid in cholesterol esters for dihomo-gamma-linoleic acid 7 h after induction of peritonitis. After 24 h the protein composition and functional activity of high-density lipoproteins was modified and the amount of saturated fatty acids in cholesterol esters increased.
机译:在实验性腹膜炎的早期阶段,研究了远亲白化病大鼠血浆脂质谱的变化和高密度脂蛋白的组成。我们发现卵磷脂:胆固醇酰基转移酶活性增加,从极低密度脂蛋白激活高密度脂蛋白的脂解生产,并在诱发腹膜炎后7小时将胆固醇酯中的花生四烯酸替换为二高-γ-亚油酸。 24小时后,高密度脂蛋白的蛋白质组成和功能活性被修饰,胆固醇酯中的饱和脂肪酸含量增加。

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