Factors of Th17 and Treg Lymphocyte Differentiation in Pulmonary Tuberculosis

摘要

In patients with infiltrative pulmonary tuberculosis, the increase in IL-6 secretion, the decrease in TGF beta production (in case of drug resistance of the causative agent), and unchanged level of IL-1 beta secretion by mononuclear leukocytes in vitro were associated with increased number of CD4(+)CD161(+)IL-17A(+) Th17 lymphocytes in the peripheral blood. In patients with disseminated drug-resistant pulmonary tuberculosis, TGF beta hyperproduction promoted differentiation of CD4(+)CD25(+)FoxP3(+) Treg lymphocytes with immunosuppressive activity.