Antitumor activity of specific immunotherapy with mucin containing CA 125 antigen in mice with CaO 1 ovarian carcinoma.

Amandzholov BS; Sitdikova SM; Lebedin YS; Chukanov SV; Toptygin AY; Manzyuk LV; Donenko FV

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Antitumor activity of specific immunotherapy with mucin containing CA 125 antigen in mice with CaO 1 ovarian carcinoma.

机译：含CA 125抗原的粘蛋白特异性免疫疗法对CaO 1卵巢癌小鼠的抗肿瘤活性。

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Experiments in CBA mice with transplanted CaO 1 ovarian carcinoma possessing common antigenic determinants with human ovarian carcinoma showed that specific immunotherapy with mucin containing CA 125 antigen inhibited tumor growth by 60% and prolonged animal lifespan by 40-60% in comparison with the control. The correlation coefficient between the tumor size and antibody titer after injection of mucin was -0.4 for IgM and -0.6 for IgG. Titration of IgG may be used for monitoring of the efficiency of specific immunotherapy.

机译：在具有人卵巢癌常见抗原决定簇的已移植CaO 1卵巢癌的CBA小鼠中进行的实验表明，与包含CA 125抗原的粘蛋白特异性免疫疗法相比，其对肿瘤的生长抑制了60％，动物的寿命延长了40-60％。注射粘蛋白后，肿瘤大小与抗体滴度之间的相关系数对于IgM为-0.4，对于IgG为-0.6。 IgG的滴定可用于监测特异性免疫疗法的效率。

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来源
《Bulletin of experimental biology and medicine 》 |2000年第4期| 共3页
作者
Amandzholov BS; Sitdikova SM; Lebedin YS; Chukanov SV; Toptygin AY; Manzyuk LV; Donenko FV;
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原文格式 PDF
正文语种 eng
中图分类基础医学 ;
关键词
CA-125 Antigen; Mucins; Ovarian Neoplasms; CA-125-Antigen; CA-125抗原; 粘蛋白类; 卵巢肿瘤;

机译：CA-125 Antigen;Mucins;Ovarian Neoplasms;CA-125-Antigen;CA-125抗原;粘蛋白类;卵巢肿瘤;

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1. Antitumor activity of specific immunotherapy with mucin containing CA 125 antigen in mice with CaO 1 ovarian carcinoma. [J] . Amandzholov BS, Sitdikova SM, Lebedin YS, Bulletin of experimental biology and medicine . 2000 ,第4期

机译：含CA 125抗原的粘蛋白特异性免疫疗法对CaO 1卵巢癌小鼠的抗肿瘤活性。
2. Expression of cancer-testis antigens as possible targets for antigen-specific immunotherapy in head and neck squamous cell carcinoma. [J] . Atanackovic D, Blum I, Cao Y, Cancer biology & therapy . 2006 ,第9期

机译：癌-睾丸抗原的表达可能是头颈部鳞状细胞癌中抗原特异性免疫治疗的靶标。
3. Improved specificity of the CA 125 enzyme immunoassay for ovarian carcinomas by use of the ratio of CA 125 to carcinoembryonic antigen. [J] . D P Knight, J A Knight, J T Wu, Clinical Chemistry: Journal of the American Association for Clinical Chemists . 1988 ,第9期

机译：通过使用CA 125与癌胚抗原的比例，可以提高CA 125酶免疫分析对卵巢癌的特异性。
4. A novel lipid-based nanopharmaceutical formulation of topotecan (Topophore CTM): Altered pharmacokinetic attributes associated with enhanced anti-tumor activity in a model of ovarian carcinoma. [C] . Annual meeting exposition of the Controlled Release Society . 2009

机译：一种新型脂质的拓扑替康（Tootophore CTM）的脂质纳米药物制剂：在卵巢癌模型中改变了与增强的抗肿瘤活性相关的药代动力学属性。
5. PD-L1-specific helper T-cells exhibit effective antitumor responses: new strategy of cancer immunotherapy targeting PD-L1 in head and neck squamous cell carcinoma. [D] . 野﨑, 結 2019

机译：PD-L1特异性辅助性T细胞表现出有效的抗肿瘤反应：针对头颈部鳞状细胞癌中PD-L1的癌症免疫疗法的新策略。
6. L1 Cell Adhesion Molecule-Specific Chimeric Antigen Receptor-Redirected Human T Cells Exhibit Specific and Efficient Antitumor Activity against Human Ovarian Cancer in Mice [O] . Hao Hong, Christine E. Brown, Julie R. Ostberg, 2011

机译：L1细胞粘附分子特异性嵌合抗原受体重定向的人类T细胞表现出针对小鼠卵巢癌的特异性和高效抗肿瘤活性。
7. L1 Cell Adhesion Molecule-Specific Chimeric Antigen Receptor-Redirected Human T Cells Exhibit Specific and Efficient Antitumor Activity against Human Ovarian Cancer in Mice. [O] . Hao Hong, Christine E Brown, Julie R Ostberg, 2016

机译：L1细胞粘附分子特异性嵌合抗原受体重定向的人T细胞在小鼠中表现出针对人卵巢癌的特异性和有效的抗肿瘤活性。
8. Prostate Cancer Immunotherapy Development in Prostate Specific Antigen Transgenic Mice [R] . Kast, W. M. 2002

机译：前列腺特异性抗原转基因小鼠的前列腺癌免疫治疗开发

Antitumor activity of specific immunotherapy with mucin containing CA 125 antigen in mice with CaO 1 ovarian carcinoma.

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